NEW CLASS OF ANTIBIOTICS DISCOVERED:
In a break-through, scientists have
discovered a new class of antibiotics to fight deadly bacteria such as
methicillin-resistant Staphylococcus aurous and other drug-resistant bacteria
that threaten public health. The new class, called oxadiazoles, was discovered
by University of Notre Dame researchers lead by May land Chang and Shahriar Mobashery
in silica (by computer) screening and has shown promise in the treatment of
MRSA in mouse models in infection. Researchers who screened 1.2 million
compounds found that the oxadiazoles inhibits a penicillin-binding protein,
PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other
drugs.